Mycotoxins from Fusarium proliferatum: new inhibitors of papain-like cysteine proteases
نویسندگان
چکیده
منابع مشابه
Interaction of papain-like cysteine proteases with dipeptide-derived nitriles.
A series of 44 dipeptide nitriles with various amino acids at the P2 position and glycine nitrile at position P1 were prepared and evaluated as inhibitors of cysteine proteinases. With respect to the important contribution of the P2-S2 interaction to the formation of enzyme-inhibitor complexes, it was focused to introduce structural diversity into the P2 side chain. Nonproteinogenic amino acids...
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Papain-like lysosomal cysteine proteases are processive and digestive enzymes that are expressed in organisms from bacteria to humans. Increasing knowledge about the physiological and pathological roles of cysteine proteases is bringing them into the focus of drug discovery research. These proteases have rather short active-site clefts, comprising three well defined substrate-binding subsites (...
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ژورنال
عنوان ژورنال: Brazilian Journal of Microbiology
سال: 2020
ISSN: 1517-8382,1678-4405
DOI: 10.1007/s42770-020-00256-7